Chronic high salt intake exaggerates renal injury and inflammation, especially with the loss of functional ETBÂ receptors. Tauroursodeoxycholic acid (TUDCA) is a chemical chaperone and bile salt that is approved for the treatment of hepatic diseases. Our aim was to determine whether TUDCA is reno-protective in a model of ETBÂ receptor deficiency with chronic high salt-induced renal injury and inflammation.
Methods:
ETB-deficient and transgenic control rats were placed on normal (0.8% NaCl) or high salt (8% NaCl) diet for 3 weeks, receiving TUDCA (400 mg/kg/day; i.p.) or vehicle. Histological and biochemical markers of kidney injury, renal cell death and renal inflammation were assessed.
Results:
In ETB-deficient rats, high salt diet significantly increased glomerular and proximal tubular histological injury, proteinuria, albuminuria, excretion of tubular injury markers KIM-1 and NGAL, renal cortical cell death and renal CD4+Â T cell numbers. TUDCA treatment increased proximal tubule megalin expression as well as prevented high salt diet-induced glomerular and tubular damage in ETB-deficient rats, as indicated by reduced kidney injury markers, decreased glomerular permeability and proximal tubule brush border restoration, as well as reduced renal inflammation. However, TUDCA had no significant effect on blood pressure.
TUDCA Complete is an all-in-one drainage and digestive support supplement that promotes healthy bile production and optimal kidney and liver function.
This blend of tauroursodeoxycholic acid (TUDCA), BioActive Carbon, N-acetyl cysteine (NAC), and six botanicals — including beetroot, marshmallow root, milk thistle, and parsley — is designed to support the kidneys and liver bile duct system as the body performs its natural detoxification processes
Conclusions:
TUDCA protects against the development of glomerular and proximal tubular damage, decreases renal cell death, and inflammation in the renal cortex in rats with ETBÂ receptor dysfunction on a chronic high salt diet. These results highlight the potential use of TUDCA as a preventive tool against chronic high salt induced renal damage.
10 TUDCA Benefits
Bile in general plays many roles in the body. From aiding in digestion to maximizing vitamin absorption or eliminating waste, bile acids support a wide range of functions.
TUDCA is a bile acid that performs its job exceptionally well. Though humans only produce a small amount of it, the benefits of TUDCA are varied and widespread. TUDCA is thought to support:*
- Brain function
- Liver health
- Kidney health
- Eye health
- Cellular health
- Gut microbiome
- Bile flow
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